Abstract
Ciprofloxacin is second generation fluoroquinolone antibiotic which is being used to treat various
infectious diseases of man and animals. Due to wide-spread use of this antimicrobial in veterinary
clinics, but little information regarding its disposition, this project was carried out to determine the PK
and optimal dosage regimen of ciprofloxacin in Nili/Ravi buffalos. Eight healthy adult buffalos of
Nili/Ravi breed (average ± SE weight of 368 ± 44 kg) were maintained under same conditions of
environment and management. A dose of 5 mg/Kg was administered in the neck muscles of each
animal through injection. After injecting drug, samples of blood were taken at various times and kept
in centrifuge tubes having heparin. In every animal, a control sample of blood was drawn before
injecting drug. HPLC was used to determine drug concentration in the samples. The value for half life
elimination (t1/2 ß) was 3.05 ± 0.20 hours. Mean ± SE value for volume of distribution (Vd) was 1.09
± 0.06 L/kg, for AUC was 20.28 ± 1.13 µg.hr/ml and for total body clearance (CL) was 0.25 ± 0.02
L/hr/kg. An optimal dosage regimen for intramuscular administration of ciprofloxacin in Nili/Ravi
buffalos was calculated using these parameters which was 17.86 mg/kg, recommended to be given
after every 24 hours. We came to conclusion that our calculated dose in local buffalos was
significantly higher than the recommended dose of manufacturer and to avoid antimicrobial
resistance, this locally investigated dosage regimen should be strictly followed in local buffalos.
Zahid Iqbal, Aamir Ali Khan, Ibadullah Jan, Muhammad Aamer Mehmood, Ijaz Javed. (2015) PHARMACOKINETICS AND DOSAGE REGIMEN OF CIPROFLOXACIN FOLLOWING SINGLE INTRAMUSCULAR ADMINISTRATION IN NILI/RAVI BUFFALOS, Asian Journal of Agriculture and Biology, Volume 3, Issue 1.
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