Abstract
Purpose: To study the effect of cyclosporine on pterygium recurrence after
primary excision
Study Design: Non randomized controlled trial.
Place and Duration of Study: The study was conducted in the department of
Ophthalmology, Liaquat University of Medical and Health Sciences, Jamshoro
from 2015 to 2017.
Material and Methods: One hundred and thirty eyes of 65 patients having
bilateral pterygium, at least 2 mm encroaching on the cornea, were selected for
study. Dimensions of pterygium were measured on slit lamp. Half of the eyes
were selected for post-operative cyclosporine and was named as cyclo- eye and
fellow other eye was named as non-cyclo eye. Immediate post-operative
treatment was tobramycin dexamethasone eye ointment twice and moxifloxacin
eye drops three times daily until corneal epithelium was restored, followed by
moxifloxacin and Cyclosporine eye drops twice daily until complete healing of
ocular surface occurred and then cyclosporine 0.05% alone once daily in the
evening up to three months. In the fellow eye tobramycin dexamethasone eye
ointment and moxifloxacin eye drops were used for complete healing time
followed by tears alone three times for three months. Follow up was done for six
months.
Results: Only Fifty-three patients who completed 6 months of follow-up were
included in the results. In cyclo-eyes recurrent pterygium was observed only in 4
(07.55%) and in non-cyclo eyes recurrence was observed in 23 (43.40%) eyes.
Mean healing time in cyclo-eyes was 21.1354 days and in non-cyclo-eyes,
15.0213 days.
Conclusion: Cyclosporine is effective in reducing the recurrence rate of
pterygium
Munawar Ahmed, Atif Mansoor, Noman Ahmed, Ghazi Khan Mari, Azfer Ahmed Mirza. (2019) Role of Topical Cyclosporine in Prevention of Pterygium Recurrence, after Primary Excision, Pakistan Journal of Ophthalmology, Volume 35, Issue 3.
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