The present study describes the antibacterial and hemolytic activities of some brominated 2-phenitidine derivatives. These synthetic molecules were screened against selected bacterial strains, i.e., gram positive and negative using streptomycin as control. The cytotoxicity of these molecules was also tested using triton as reference. The study revealed that the analyzed molecules displayed moderate potential as antibacterial agents; however, these might serve as valued hemolytic agents.