• Asif Nawaz,

• Gul Majid Khan

• Shefaat Ullah Shah

• Kifayat Ullah Shah,

• Asim-ur-Rehman

• Abid Hussain

Abstract

The present study was conducted to formulate and evaluate transdermal patch of Clotrimazole for local as well as systemic therapy of severe to moderate fungal infections. The penetration effect of naturally occurring oil [Olive oil] was investigated on the in vitro penetration enhancement of Clotrimazole across synthetic membrane as well as albino rabbit skin. Clotrimazole was evaluated for its particle size and particle size distribution analysis by using Particle size analyzer [Horiba LA 300]. Clotrimazole patches were formulated by solvent evaporation method for in vitro drug penetration studies. Olive oil was added to some selected formulations at different concentrations i.e. 0.5, 1, 1.5, 2, 2.5 and 3% to see their effect on drug release patterns.The formulated patches were evaluated for various physico-chemical parameters to check their suitability for topical application. Franz diffusion cell Apparatus [Perm Gear, USA] was used for in vitro drug release studies having phosphate buffer pH 7.4 as receptor solvent.

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