Abstract
Exogenous administration of testosterone propionate to normal male rats accelerated the process of skeletal muscle fibre's regeneration following orthotopic transplantations of extensor digitorum longus muscles. At one-week postgrafting period the hormone supplemented muscle grafts were found to attain significantly higher average cross-sectional area of the regenerated muscle fibres than those in the control transplants. The steroid exerted its pronounced anabolic effects during the early phase of muscle regeneration and the experimental grafts looked also better in terms of less deposition of connective tissue and earlier completion of degeneration-regeneration course than the control regenerates. In the later stages of regeneration cross-sectional areas of the regenerated muscle fibres were comparable in both categories of the grafts, however, number of the regenerated muscle fibres appeared higher in the hormone supplied transplants accompanied with little connective tissue deposition.
JAVED I. QAZI , SHAHZAD A. MUFTI . (1998) REGENERATION OF EXTENSOR DIGITORUM LONGUS MUSCLE GRAFTS IN TESTOSTERONE PROPIOATE SUPPLEMENTED RATS, Punjab University Journal of Zoology, Volume 13, Issue 1.
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