Abstract
Out of 46 rabbits acclimatized for 2 weeks to the optimal conditions of animal house, 23 were inoculated upto 7 weeks with different doses (0.50, 0.75, 1.0, 1.25, 1.50, 1.50. 1.50 ml) of filtered hydatid cyst fluid (FHCF) of sheep origin. Ea& dose was daily inoculated for one week and then calculated according to their body weight. Control rabbits were given distilled water with similar protocol. Three treated and three control rabbits were weekly slaughtered and biochemical analyses of liver tissue were made. It was noted that body weight increased gradually in both control aad experimental rabbits but when both groups were compared, a significant reduction was noted for all the rabbits treated with FHCF except the last three doses which were kept constant. Their respective specific growth rate also showed increasing trend but with lot of fluctuations. In the liver tissues of treated Obits increase in total protein, soluble protein (P<0.001), glutamate oxaloacetate transaminase (P<0.001), glutamate pyruvate transaminase (P<0.01), bilirubin (P < 0.05), alkaline phosphatase (P <0.001), acid phosphatase, ribonucleic acid, deoxyribonucleic acid and free amino acid was found statistically significant when compared with their respective centrols, while cholesterol level decreased in all the treated rabbits.
AKHTAR TANVEER, SHAZIA SAEED , ZAHEER ANWAR. (1997) SOME METABOLIC ALTERATIONS INDUCED BY HIGH DOSES OF UNILOCULAR FILTERED HYDATID CYST FLUID ON RABBIT LIVER , Punjab University Journal of Zoology, Volume 12, Issue 1.
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