Abstract
Danitol, a synthetic pyrethroid, force fed to a group of male domesticated rabbits at a dose of 10mg/kg body weight per day for seven days, produced significant abnormal changes in the blood and liver. The red blood cell count, haemoglobin content and mean corpuscular haemoglobin were significantly decreased (15%, 14% and 31%, respectively), whereas white blood cell count increased 46%. The blood serum glutamate oxaloacetate transaminase activity and bilirubin content increased 76% and 67%, respectively after 4 days of treatment, whereas alkaline phosphatase and acid phosphatase activities, and concentrations of protein and cholesterol decreased 54%, 19%, 15% and 26%, respectively after 4 days of treatment. All other biochemical parameters including liver function tests remained unchanged. In liver only isocitrate dehydrogenase activity showed a significant increase after 7 days treatment, whereas all other hepatic biochemical components remained unaltered
ABDUL RAUF SHAKOORI , UZMA BUTT, RAHILA RIFFAT , FARAH AZIZ. (1992) TOXIC EFFECTS OF SHORT-TERM ORAL ADMINISTRATION OF DANITOL ON THE BLOOD AND LIVER OF RABBITS, Punjab University Journal of Zoology, Volume 7, Issue 1.
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