Abstract
Takayasu arteritis (TKA) is a rare large vessel vasculitis occurring in young adults of less than 50 year of age.Weanalyse the clinical, radiological features, and treatment regimensin Pakistani patients presentingto a tertiary care center. Methods:A retrospective cross-sectional analysis of TKA patients done at the Rheumatology department of Fatima Memorial Hospital. A comprehensive evaluation of clinical, laboratory, radiographic features and treatment regimens was carried out.Results:A consecutive cohort of 18 patients, with 13 patients (72%) of female gender was studied. Mean age of the cohort was 35.94±2.7 years.A mean delay of 2.32±0.43 years between symptoms and final diagnosis was reported, attributed toalternate diagnosis in 57.1% and late presentation in 42.8% cases.Limb claudication(44.4%), absent pulses (38.9%),were the common initial manifestation. Hypertension (61.5%),blood pressure discrepancy between arms(88.9%) and bruit (72.2%) over major vessels were common systemic features. As per angiographic classification, Type V (44.4%),and Type I (33.3%), were most common pattern of disease in the cohort. Subclavian artery (72.2%), renal artery (33.3%),iliofemoral arteries (27.8%), and coronary artery involvement (16.7%) were the common lesions. Coronary artery lesion was higher in females (p=0.52) while renal artery lesion inmales (p=0.27). There was no statistically significant difference in involvement of vessels according to gender (p >0.05).Conclusion: Type V and Type I are the common pattern of TKA.Limb claudication was the most common initial manifestation. Renal artery involvement was seen more commonly in males while coronary artery involvement more commonly in females.
