Abstract
Eclampsia andpreeclampsia are among the serious complications ofgestation and threaten the lives of both mother and foetus. A protein called visfatin, one of these adipokines,is evaluated for its effects on serum electrolytes, lipid profile and hepatic enzymes in preeclamptic and eclamptic patients.Methods: Asum of 234 pregnant women were enrolled in this cross-sectional study and divided in to 2main groups, i.e., Group A (eclamptic/preeclamptic) Group B(control) pregnant women respectively. Serum visfatin levels (ng/mL), serum electrolytes andliver enzymeswere determined for every patient, using relative diagnostic kits.Anthropometric measurements were also noted. Results: A total of 234 women (cases; n=160, controls; n=74) with gestation age of ≥20 weeks participated in this study. Group A had 86 (36.75%) women with preeclampsia and 74 (31.62%) women with eclampsia whereas Group B had 74 (31.62%) normotensive pregnant women.A strong significantly positive association was recorded for systolic (R2=78.78; p-value <0.000) and diastolic blood pressure (BP) (R2=78.52; p-value <0.000). Similar result was obtained for serum sodium ions (R2=3.09; p-value <0.002) and chloride ions (R2=7.36; p-value <0.000). Alkaline phosphatases (ALP) (R2=63.47; p-value <0.000) had also shown a strong positive and statistically significant association with visfatin levels. Conclusion:Serumvisfatinsignificantly decreased the sodium and chloride levels whereas the levels of potassium remained unaffected. A very strong and positive association of visfatin levels with levels of bilirubin and alkaline phosphatases was also observed (ALP) but it found no effect on aspartate transferases (AST)
Muhammad Waqas Luqman, Asmat Shaheen, Sofia Iqbal, Nida Khan, Sadia Fatima, Rubina Nazli. (2022) RELATIONSHIP OF SERUM VISFATIN LEVELS WITH SERUM ELECTROLYTES, LIVER PROFILE, HEPATIC ENZYMES AND ANTHROPOMETRIC PARAMETERS IN PREGNANT WOMEN WITH PREECLAMPSIA AND ECLAMPSIA DURING 3RD TRIMESTER, JOURNAL OF AYUB MEDICAL COLLEGE ABBOTTABAD, Volume 34, issue1.
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