Abstract
Background: Vanadyl sulphate is available as herbal medicine against diabetes mellitus and body building supplement, over the counter worldwide. The available data on its safety is controversial and inadequate. The objective of this study was to analyse its safety in usual therapeutic dose range.Methods: It was an experimental study carried out at theDepartment of Biochemistry & Molecular Biology, Army Medical College, National University of Medical Sciences (NUMS), Rawalpindi, Pakistan, from Jun 2014 to Oct 2018.The study was carried out on 105 Sprague Dawley rats for duration of 24 weeks. The animals were randomly distributed in three groups of 35 each. Thegroup Irats were markedas control while rats of group II & IIIwere administeredvanadyl sulphate 0.06mg/dayand 0.3mg/day respectively. Alanine amino transferase (ALT) and Malondialdehyde (MDA) were measured in serum while comet assay was performed on WBCs. Results: The plasma levels of ALTand MDAwere significantly raised in group IIand IIIsubjects. Single cell gel electrophoresis (SCGE) / comet assay showed minimal “tail moment” in control groupand increased tail moment in group II and III in a dose dependent manner which indicates dsDNA breaks. Conclusion: It was observed that vanadyl sulphate causes hepatocellular toxicity, oxidative stress and damage to the DNA in usual therapeutic/ supplemental doses. Due to hazardous effects, its use in humansas alternate medicine may be reviewed
Amir Rashid, , Abdul Khaliq Naveed, , Saleem Ahmed Khan,, Sarwat Jahan. (2019) GENOTOXIC AND CYTOTOXIC EFFECTS OF ORAL VANADYL SULPHATE, JOURNAL OF AYUB MEDICAL COLLEGE ABBOTTABAD, Volume 31, Issue 4.
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