Abstract
Background: Patients with haematological malignancies and stem cell transplant recipients are at high risk of opportunistic infections. Little international and no national data is available comparingnoble metal coated versus uncoated central venous catheters (CVC) in this special population of severely immunocompromised patients.Objective of the study is tocompare infectious and non-infectious complications of noble metal coated versus uncoated central venous catheters in patients undergoing stem cell transplantation and receiving chemotherapy for acute myeloid leukaemia.Methods: This is a prospective, cross-sectional,randomized study (January to December 2016), enrolling 45consecutive patients undergoing stem cell transplantation or chemotherapy for acute myeloid leukaemia. Patients were randomized in 2 groups. Twenty 23patients receivedstandard CVC and 22 patients received CVC catheters coatedwith three noble metals (Gold, Silver, Palladium). Patients were observed for catheter related infectious and non-infectious complications. Data was analysed using SPSS.Results: Meanage was 24.3 (±4.91) in uncoated and 25.09 (±5.22) in coated CVL group. CRBSI infection was detected in 2 (8.6%) and 3 (13.6%) patients in uncoated and coated group respectively with p-value of .279. There was no statistically significant difference in febrile episodes between coated (95.4%) and uncoated (91.3%) group. While we considered non-infectiouscomplications, 2 patients in coated (8.6%) and 1 in uncoated CVCs group (4.3%) had CVC thrombosis which was not significant statistically.Conclusion: Therewas no efficacy of BG-thin noble metal coated CVCs in reducing infectious and non-infectious complications (thrombosis)in our study
Raheel Iftikhar,, Qamar Un Nisa Chaudhry, Tariq Mehmood Satti, Syed Kamran Mahmood, Humayun Shafique Satti, Tariq Ghafoor, Mehreen Ali Khan. (2019) NOBLE METAL COATED CENTRAL VENOUS CATHETERS ARE NOT SUPERIOR TO UNCOATED CATHETERS IN PREVENTING INFECTIOUS AND NON-INFECTIOUS COMPLICATIONS IN IMMUNOCOMPROMISED PATIENTS, JOURNAL OF AYUB MEDICAL COLLEGE ABBOTTABAD, Volume 31, Issue 1.
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