Abstract
The inability to undisputedly distinguish reactive mesothelial cells from metastatic adenocarcinoma cells exfoliated in serous effusions is the most common difficulty encountered by pathologists. Ancillary studies are being useful in improving the accuracy of cytological diagnosis. From all the available methods, Immunochemical stains have excelled in the diagnosis of effusion cytology.A combination of epithelial and mesothelial markers is recommended, as use of a single marker alone can’t establish the diagnosis.In present study, we aimed to distinguish adenocarcinoma cells from reactive mesothelial cells with the help of a panel of immunomarkers including; two epithelial cell markers; Ber-EP 4 and MOC 31, and two mesothelial markers; Calretinin and HBME1.
Objective: To differentiate reactive mesothelial cells and adenocarcinoma cells by using immunocytochemical markers (Ber-EP 4, MOC-31, Calretinin and HBME-1) in serous effusions.
Faiza shabir, Muhammad ahasn iqbal, sameer anjum, Abdul hannan Nagi. (2018) DIFFERENTIAL DIAGNOSIS OF REACTIVE MESOTHELIAL CELLS AND ADENOCARCINOMA CELLS USING IMMUNOCYTOCHEMICAL MARKERS (BER-EP 4, MOC-31, CALRETININ AND HBME-1) IN SEROUS EFFUSIONS, International Journal of Pathology, volume16, jul-sep.
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