Abstract
OBJECTIVE: To assess biochemical markers after administering Taraxacum
officinale's extract in cisplatin induced nephrotoxic albino mice.
METHODS: It was an experimental study, carried out on thirty albino mice
categorized into six groups i-e. normal control (saline only), negative control
(cisplatin-25mg/kg body weight intraperitoneally) and experimental groups (E1
to E4) (Taraxacum officinale's extract at doses 100 mg, 200 mg, 400 mg and 800
mg per kg body weight respectively intraperitoneally followed by single dose of
cisplatin-25 mg/kg body weight intraperitoneally). Effects of Taraxacum
officinale's extract on kidney were assessed by biochemical markers i-e. blood
urea and creatinine.
RESULTS:Comparison of blood urea levels in experimental groups (E1, E2, E3
& E4) was much lowered (242±36.6 mg/dl, 176.8±23.9 mg/dl, 179.4±69.5
mg/dl, 186.6±69.05 mg/dl respectively) than the negative control (363±111.1
mg/dl) [p value < 0.05]. Comparison of serum creatinine in negative control
versus experimental groups respectively was decreased but statistically
insignificant (serum creatinine levels of experimental groups were 1.60±0.65
mg/dl, 1.89±0.32 mg/dl, 1.66±0.62 mg/dl, 1.84±0.55 mg/dl while serum
creatinine of negative control was 1.97±1.06 mg/dl) [p value > 0.05].
CONCLUSION: Taraxacum officinale's extract (dandelion) significantly
reduces the effects of renal toxicity produced by the cisplatin but was unable to
completely revert cisplatin-induced nephrotoxicity in mice.
Amber Javaid, Shafaq Zafar, Munaza Khattak, Farzana Khan, Shamaila Wadud. (2019) EFFECTS OF ADMINISTRATION OF TARAXACUM OFFICINALE'S EXTRACT ON RENAL PARAMETERS IN CISPLATIN INDUCED NEPHROTOXICITY IN ALBINO MICE, KHYBER MEDICAL UNIVERSITY JOURNAL, Volume 11, Issue 3.
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