Abstract
OBJECTIVE: To assess the effects of prophylactic antenatal dexamethasone
administration in reducing the neonatal respiratory morbidity at term after
elective lower segment caesarean section (LSCS).
METHODS: This open label randomized-controlled trial was conducted in
Department of Obstetrics and Gynaecology, Kahuta Research Laboratories
(KRL) Hospital, Islamabad from September 2017 to February 2018. Patients
with singleton pregnancy and non-anomalous fetus between gestational age of
0 6
37+ and 38+ , planned to be delivered by elective LSCS were randomized
through block-randomization method into interventional group (A): who
received dexamethasone and control group (B): who did not receive
prophylactic dexamethasone. Main outcomes of the study included Apgarscore at one & ve minutes, admission to neonatal intensive care unit (NICU)
due to transient tachypnea of newborn (TTN) and respiratory distress
syndrome (RDS). Data was analyzed by SPSS version 23.
RESULTS: A total of 304 women were randomized and equally assigned to
interventional and control group. In group-A, 2 neonates developed RDS as
compared to one neonate in group-B (p=0.391). Mean age of patients in group
A and B was 30.48±4.18 years and 29.38±4.57 years respectively. Fiveminutes Apgar score was 8.91±0.290 in group A & 8.87±0.393 in group B
(p=0.320). TTN developed in four neonates in group-A while one neonate in
group-B (p=0.176). Eighteen (11.8%) cases in group A & 12(7.9%) cases in
group B were admitted in NICU (p=0.249).
CONCLUSION: Prophylactic dexamethasone administration in term LSCS
after 37 weeks of gestational age has no signicant effects on reducing the
incidence of RDS, TTN and neonatal admission to NICU.
Hasina Sadiq, Irum Sohail. (2019) EFFECTS OF PROPHYLACTIC MATERNAL DEXAMETHASONE ADMINISTRATION ON THE NEONATAL RESPIRATORY OUTCOMES AT TERM AFTER ELECTIVE CAESAREAN SECTION: RANDOMIZED CONTROLLED TRIAL, KHYBER MEDICAL UNIVERSITY JOURNAL, Volume 11, Issue 1.
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