Abstract
OBJECTIVES: To use biochemical parameters and FibroScan as noninvasive
tool in determination of various stages of liver brosis in chronic hepatitis C virus
(HCV) patients.
METHODS: Total 759 participants (609 chronic HCV patients and 150 normal
healthy controls) were recruited from Lady Reading hospital and Al-Hayat
Medical Center, Dabgri garden, Peshawar, Pakistan and analyzed for
biochemical markers from February 2015 to January 2017. On the basis of liver
stiffness, 609 HCV patients were categorized in 05 groups as per FibroScan
ndings that include patients with no brosis, mild brosis, moderate brosis,
severe brosis and cirrhosis. Only those HCV patients who showed presence of
HCV RNA (PCR assay) in serum were included in this study. HCV patients who
were co-infected with Hepatitis B virus and HIV were excluded from this study.
RESULTS: Advance staged disease patients with severe liver brosis and
cirrhosis showed elevated level of aspartate aminotransferase (AST), alanine
aminotransferase (ALT), gamma-glutamyl transferase (GGT), alkaline
phosphatase (ALP), AST/ALT, total bilirubin and lower level of albumin and
haptoglobinas compared to controls and were found statistically signicant
(P<0.01). Patients group with cirrhosis showed elevated level of AST, ALT,
GGT, ALP, AST/ALT and total bilirubin when compared to patients group with
no liver complications and were statistically signicant (P<0.01). Albumin and
haptoglobin were signicantly lower (P<0.05) in cirrhotic patients compared to
those without liver complications.
CONCLUSION: Combination of FibroScan and routinely available
biochemical parameters are helpful in identifying liver brosis and cirrhosis in
chronic HCV patients.
Abdur Rahim, Tanveer Shafqat, Rubina Nazli, Ghosia Lutfullah, Sadia Fatima, Aqsa Zubair. (2019) NONINVASIVE PARAMETERS AND STAGING OF LIVER FIBROSIS IN CHRONIC HEPATITIS C PATIENTS, KHYBER MEDICAL UNIVERSITY JOURNAL, Volume 11, Issue 1.
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