Abstract
OBJECTIVE: To study changes in retinal nerve fiber layer (RNFL) measured on
optical coherence tomography (OCT) after panretinal photocoagulation (PRP)
in patients with proliferative diabetic retinopathy (PDR).
METHODS: This quasi experimental study was conducted at Department of
Ophthalmology, Lahore General Hospital, Lahore from 1-4-2017 to 30-3-2018.
All patients (n=38) diagnosed with PDR requiring PRP were included. Patients
having any coexisting ocular pathology hindering the OCT measurement were
excluded. Pre-operatively, RNFL thickness in four quadrants and signal strength
was measured on OCT and visual acuity (VA) on Snellen's chart. Postoperatively, patients were followed-up after one-month and three-months and
VA was measured and OCT performed.
RESULTS: The mean age of patients was 60.66±5.51years with 23(60.5%)
males. PRP was performed in right-eye of 22 patients. Pre-laser VA in 28
patients was 6/60. Pre-laser total RNFL was 84.32±4.78µm reduced to
83.74±4.61µm one-month and 81.89±4.40µm three-months post-laser
(p<0.001). Pre-laser, superior RNFL thickness was 84.97±4.13µm, reduced to
84.39±3.95µm one-month and to 82.21±3.84µm at three-months post-laser
(p 0.024). Pre-laser inferior RNFL thickness was 84.89±4.68µm, reduced to
84.00±4.44µm one-month and to 81.71±4.50µm three months post-laser
(p=0.032). Pre-laser temporal RNFL thickness was 83.26±3.47µm, reduced
to 82.34±3.44µm one-month and to 80.21±3.49µm three-months post-laser
(p<0.001). Pre-laser nasal RNFL thickness was 85.16±3.78µm, reduced to
84.26±3.88µm one-month post-laser and to 82.08±3.74µm at three-months
post-laser (p=0.043). Pre-laser, signal strength on OCT was 8.26±0.69 and
8.66±0.48 after one-month post-laser and 8.55±0.50 at three-months laser
(p=0.009).
CONCLUSION: PRP leads to a decrease in thickness of RNFL after one month
and three months as compared to pre-laser RNFL thickness.
Muhammad Shaheer, Arooj Amjad, Asima Rafique. (2018) CHANGES IN RETINAL NERVE FIBER LAYERON OPTICAL COHERENCE TOMOGRAPHYAFTER PANRETINAL PHOTOCOAGULATIONIN PATIENTS WITH PROLIFERATIVEDIABETIC RETINOPATHY, KHYBER MEDICAL UNIVERSITY JOURNAL, Volume 10, Issue 4.
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