Abstract
OBJECTIVES: To compare the image findings with histopathological diagnosis
on ultrasound guided (USG) percutaneous biopsies of liver lesions in relation to
hepatocellular carcinoma (HCC) and to assess the role of hepatitis B virus
(HBV) and hepatitis C virus (HCV) in evolution of HCC.
METHODS: This descriptive cross-sectional study included biopsies
performed on patients reporting to Kuwait Teaching Hospital, Peshawar,
Pakistan from 01-07-2017 to 30-09-2017. The patient selection was based on
findings on various image modalities like triphasic liver computed tomography
(CT) or dynamic magnetic resonance imaging (MRI), in which percutaneous
liver biopsy was indicated. The biopsies were routinely processed for
histological examination on hematoxyllin and eosin stain and application of
immunohistochemical stains for detecting HCC.
RESULTS: A total number of 82 USG percutaneous biopsies were performed
on various sites out of which 41 (50%) were performed on liver lesions. On
imaging 12 (30%) were diagnosed as hepatocellular carcinoma whereas 16
(39%) cases were confirmed on histopathology, which either showed Hep-Par-
1 or arginase positivity. On imaging 11/16 (68.75%) were either diagnosed as
HCC or were suspicious of it. A sensitivity of 75% and specificity of 95% was
calculated for diagnosis of HCC on imaging. The correlation between image and
biopsy diagnosis of HCC was statistically significant (p value 0.05).
CONCLUSION: The present study concludes that image findings are helpful in
the initial diagnosis of HCC which shows an increasing trend to be associated
HCV as compared to HBV with a remarkably declining trend.
Abdul Majid, Muhammad Mumtaz Khan, Abdul Aziz Zia, Sadaf Alam. (2018) COMPARISON OF IMAGE FINDINGS WITH HISTOPATHOLOGICAL DIAGNOSIS ON ULTRASOUND GUIDED PERCUTANEOUS LIVER BIOPSY IN RELATION TO HEPATOCELLULAR CARCINOMA, KHYBER MEDICAL UNIVERSITY JOURNAL, Volume 10, Issue 4.
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