Abstract
OBJECTIVE: To determine the correlation of serum immunoglobulin E (IgE)
levels with asthma severity in children (2-12 years) presenting to Pediatric
Outpatient Department, Liaquat National Hospital, Karachi.
METHODS: A descriptive cross-sectional study was done at Department of
Pediatric Medicine, Liaquat National Hospital, Karachi from June 2016 to
December 2016. A total of 106 children with symptoms of airflow obstruction
characterized by recurrent cough, difficulty in breathing and wheeze were
included in this study. The severity of asthma were classified as intermittent,
mild, moderate or severe persistant asthma based on subjective experience of
the patients. Blood samples for serum IgE levels were taken and serum IgE levels
were estimated by automated chemiluminescence system.
RESULTS: The average age of the children was 6.38±6.0 years. In this study,
intermittent asthma was observed in 24 (22.64%) cases. There were 30
(28.6%) children with mild asthma, 40 (37.74%) children with moderate
asthma and severe asthma was found in 12 (11.32%) children. The mean IgE
concentration was lowest in children with intermittent asthma (277.92±45.87
IU/ml), higher in children with mild persistent asthma (487.47±58.47 IU/ml)
and highest in children with moderate and severe persistent asthma
(688.75±52.08 and 1078.83±64.10IU/ml), respectively. .
CONCLUSION: Our results support the hypothesis that severity of asthma is
reflected by serum IgE levels in children. We found that the mean IgE
concentration correlates with the severity of asthma, being highest in the
patients with severe asthma and dropping down as the symptoms wane.
Muhammad Athar Ahmed, Muhammad Nadeem Chohan, Kashif Abbas, Samina Shamim. (2018) CORRELATION OF SERUM IMMUNOGLOBULINE LEVELS WITH ASTHMA SEVERITY INCHILDREN (2-12 YEARS) PRESENTINGTO A TERTIARY CARE HOSPITAL, KHYBER MEDICAL UNIVERSITY JOURNAL, Volume 10, Issue 4.
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