Abstract
OBJECTIVES: To assess and compare anti-inflammatory effect of pioglitazone
and gemfibrozil by measuring C-reactive protein (CRP) levels in high fat fed
non-diabetic rats.
METHODS: A comparative animal study was conducted at the Post Graduate
Medical Institute, Lahore, Pakistan in which 27 adult healthy male Sprague
Dawley rats were used. The rats were divided into three groups.
Hyperlipidemia was induced in all three groups by giving hyperlipidemic diet
containing cholesterol 1.5%, coconut oil 8.0% and sodium cholate 1.0%. After
four weeks, Group A (control) was given distilled water, Group B was given
pioglitazone 10mg/kg body weight and Group C was given gemfibrozil 10mg/kg
body weight as single morning dose by oral route for four weeks. CRP was
th th estimated at zero, 4 and 8 week.
RESULTS: There was significant increase in the level of CRP after giving high
lipid diet from (mean±SD) 2.59±0.28mg/L, 2.63±0.32mg/L and
2.67±0.23mg/L at 0 week to 3.55±0.44mg/L, 3.59±0.34mg/L and
th 3.6±0.32mg/L at 4 week in groups A, B and C respectively.
Multiple comparisons by ANOVA revealed significant difference between
th groups at 8 week only. Post hoc analysis disclosed that CRP level was
significantly low in pioglitazone treated group having mean±SD of
2.93±0.33mg/L compared to control group 4.42±0.30mg/L and gemfibrozil
group 4.28±0.39mg/L. The p-value in each case was <0.001, while difference
between control and gemfibrozil was not statistically significant.
CONCLUSION: Pioglitazone is effective in reducing hyperlipidemia
associated inflammation, evidenced by decreased CRP level while gemfibrozil is
not effective
Mazhar Hussain, Mahwash Malik, Zujaja Zaheer, Sadia Chiragh. (2018) EFFECT OF PIOGLITAZONE AND GEMFIBROZIL ADMINISTRATION ON C-REACTIVE PROTEIN LEVELS IN NON-DIABETIC HYPERLIPIDEMIC RATS, KHYBER MEDICAL UNIVERSITY JOURNAL, Volume 10, Issue 3.
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