Abstract
Staphylococcus aureusis apotential pathogen of hospital and community related infections. Itsecretes toxins or the enzymes as virulence factor of mild to severe infections and show resistance tobeta-lactam antibioticincluding penicillin, methicillin, oxacillin and now vancomycin that couldalarm of equal risk factors of Methicillin ResistantStaphylococcus aureus(MRSA) infections inthepatients.The survey report of 381 patients of Hyderabad, Pakistan was collected from March 2013to June 2014 in which 176 cases were reported forStaphylococcus aureusin both genders ofdifferent age groups of3-15 y kids, 16-45 y adults and 45-70 yolds, which showed 208 and 132specimensStaphylococcus infectionand 16 and 4cases of MRSA infections in male and femalepatients,respectively whereas other 31 cases showed no infection.The laboratory diagnosis of the200 samples from various hospitalized patients revealed the highestpercentage ofMethicillinResistantStaphylococcus aureusMRSA in pus and post-operative wounds (17%) followed by skinswabs (10%), sputum (7%) and blood (0%).The observations revealed greater prevalence ofMRSA infectionin elderly age 16-45 years males than the females and other age groups.Antibiotic susceptibility test of 26 antibiotics revealed resistance (R-53%), sensitive (S-39) andvariable (V-7%) sensitivity zones (mm).Amplification ofmecAgene was doneusing PCRreaction that revealedmecAgene bands up to 150-200 base pairs by test resistant strains.
Nazir Ahmed Brohi, AghaAsad Noor. (2017) Frequency of the Occurence ofMethicilin ResistantStaphylococcus aureusInfections in Hyderabad,Pakistan, Pakistan Journal of Analytical & Environmental Chemistry, Volume 18, Issue 1.
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