Abstract
OBJECTIVES: To determine the frequency of microbiologically con-firmed urinary tract infection (UTI), pattern of causative organisms and their antimicrobial susceptibility in uncontrolled diabetic patients with gross pyuria.METHODS: This study was conducted at Department of Medicine, Divisional Headquarter Hospital KDA Kohat and Qazi Medical Cen-tre, Kohat- Pakistan, from January 2015 to December 2015. Ninty six adult diabetic patients having uncontrolled glycemia (Random blood sugar>200mg/dl) with gross pyuria (>100 pus cell/HPF on urinalysis) and not taking any antibiotic for the last 3 days were enrolled in study. Urine of patients was sent for culture and sensitivity.RESULTS: Out of 96 patients, 88 (91.66%) were having Type 2 Diabetes Mellitus and 8 (8.33%) had Type 1 Diabetes Mellitus. Patients were ranging in age from 19-70 years with mean age of 51.156±12.54 years. Out of 96 tested urine samples, 80 (83.33%) were with positive urine culture report while in 16 (16.67%) cases no significant growth of any microorganism was obtained. Out of these 80 positive cases, E.Coli was the most frequent isolate in 68 (85%) samples followed by Proteus in 7 (8.75%) samples. Isolated E.Coli showed 100% sensitivity to Piperacillin plus Tazobactum and Imipinem but 100% resistance was observed to Naladixic Acid, Norfloxacin and Ciprofloxacin.CONCLUSION: Diagnostic yield of urine culture and sensitivity in un-controlled diabetic patients with gross pyuria was 83.33%. Escherichia coli were found to be the most predominant isolate, showing high drug resistance particularly to naladixic acid, ciprofloxacin and norfloxacin.
Syed Fahim Shah, Sohail Aziz Paracha. (2016) GROSS PYURIC DIABETICS WITH UNCONTROLLED GLYCEMIA: PATTERN OF PATHOGENIC ORGANISMS AND ANTIMICROBIAL SUSCEPTIBILITY, KHYBER MEDICAL UNIVERSITY JOURNAL, Volume 8, Issue 4.
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