Abstract
Purpose: To find the efficacy of topical tetracycline in corneal neovascularization.Material and Methods: In this prospective observational clinical analysis,patients more than fifteen year’s age of either sex were enrolled. Anteriorsegment slit lamp examination was performed. Fluorescein 1% dye and rosebengal were used to stain cornea at the bed and margins simultaneously. Thearea of corneal vascularization was measured in mm using 0.5% fluoresceindye. The percentage of neovascularized corneal areas to the entire cornea wascalculated.Result: Out of twenty eight patients twenty one completed follow up period offour months. Among 21 patients males were 10 (47.6%), and females 11(52.38%) with unilateral and bilateral corneal neo-vascularization. 15 (71.42%)responded well and showed reduction in corneal new vessels from 7 mm pretreatmentto 2 mm (overall) post treatment at the end of fourth month. six patientshowed poor or no response due to extended fibrosis.Conclusion: Topical tetracycline has remained quite instrumental in reducingsuperficial epithelial and sub-epithelial corneal new vessels.Key Words: Cornea; Neovascularization; Tetracycline; Therapeutic effect
Arshad Ali Lodhi, Murtaza, Munawar Ahmed, , Noman Ahmed Ghulam Haider, Sameen Afzal Junejo, Mustafa Kamal. (2015) Role of Tetracycline in Corneal Neovascularization, Pakistan Journal of Ophthalmology, Volume 31, Issue 3.
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