Abstract
Purpose: To evaluate the efficacy of monthly intravitreal bevacizumab injections (1.25 mg/.05 ml) in improving or stabilizing visual outcomes measured by Snellen’s visual acuity charts for diverse ocular diseases. Material and Methods: This was a prospective hospital based study in which a total number of 108 eyes of 80 patients were included with various ocular diseases. Maximum three intravitreal bevacizumab injections 1.25mg in 0.05ml each was given over a period of 3 months and follow up for 06 months after the first injection was carried out. The criteria for improvement was a gain of at least one line on Snellen’s visual acuity chart, compared to the baseline while stabilization was considered if the visual acuity was unchanged relative to the baseline.Results: A total number of 108 eyes of 80 patients were included in the study. Males were 40 and females were also 40 with an age range of 32-70 years. They were subjected to intravitreal injection of bevacizumab. Ten eyes (62.5%) with neovascular age related macular degeneration (ARMD) showed improvement while visual acuity was stabilized in 06 eyes (37.5%). In diabetic macular edema (DME) 30 eyes (68.1%) showed improvement, 10 eyes (22.7%) were stabilized and in 04 eyes (9%) visual loss continued. In patients with proliferative diabetic retinopathy (PDR) with vitreous hemorrhage 30 eyes (93.7%) showed improvement while stabilization of visual acuity was noted in 02 eyes (6.2%). In central retinal venous occlusion (CRVO) 04 eyes (80%) showed improvement and stabilization occurred in 01 eye (20%). Out of the 08 eyes of branch retinal venous occlusion (BRVO) all eyes showed visual improvement (100%). All 03 eyes (100%) of myopic choroidal neovascular membrane (CNV) patients also showed improvement. No systemic side effects of the given treatment were observed.Conclusion: The treatment with Bevacizumab is beneficial in improving and stabilizing visual acuity not only in neovascular ARMD but also in otherchorioretinal vascular disorders.
Adnan Afaq, Erum Shahid, Khwaja Sharif ul Hasan. (2013) Effectiveness of Intravitreal Bevacizumab in Various Ocular Diseases, Pakistan Journal of Ophthalmology, Volume 29, Issue 2.
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