Abstract
Present study aims to investigate the protective effects of Panax ginseng extract (PGE) following middle cerebral artery occlusion/reperfusion (MCAO/R) model in relation to post-stroke neurobehavioral changes.
Age and sex-matched Wistar rats of body weight 200 ± 20g were randomly divided as group I- (control group), group II (sham group), group III (MCAO/R, stroke group) and group IV (MCAO+PGE treated group). Group IV animals were orally administered with panax ginseng extract 10mL/day for thirty days. After one month MCAO/R surgery was employed to group IV animals. At the end of experimental period, all groups were tested for ischemic stroke-related sensorimotor changes via battery of neurobehavioral tests including neurological deficit score, corner turn test, vibrissae-evoked forelimb placing test (a) ipsilesional limb and (b) contralesional limb placement, foot-fault test and wire-hanging maneuver.
PGE treatment showed consistent and significant (P<0.05) improvement in neurobehavioral activities following MCAO/R injury as expressed by significant reduction in ND score, significant improvement in contralesional & ipsilesional forelimb placement, foot faults, corner?turn and wire hanging maneuver.
PGE consumption has significant protective effect against ischemia-reperfusion associated neuronal injury as assessed by recovery of neurobehavioral functions.
MUFZALA SHAMIM, NAZISH IQBAL KHAN. (2018) PREEMPTIVE EFFECT OF PANAX GINSENG EXTRACT ON SENSORIMOTOR DYSFUNCTION IN EXPERIMENTALLY INDUCED MIDDLE CEREBRAL ARTERY OCCLUSION-REPERFUSION INJURY MODEL OF ISCHEMIC STROKE., fuuast Journal of Biology, Volume 8, Issue 2.
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