Abstract
The objective of this study was to explore the scientific basis of traditional usage of Phyllanthus emblica
as an anti-diabetic agent in hyperglycemic patients. Ethanolic extract of its dried fruits was analyzed both
qualitatively and quantitatively for evaluation of phytochemical agents. Then its antioxidant and anti-diabetic
activities were found. The results indicated the presence of carbohydrates, tannins, phenols, alkaloids,
flavonoids, saponins, glycosides, amino acids and proteins in crude extract with phenolic and flavonoid contents
observed as 9.9 mg/g equivalent of gallic acid and 100 mg/g equivalent of rutin, respectively. Free radical
scavenging activity by plant extract was observed as 68±0.33 % as compared to rutin (58±1.15 %) at
concentration 2.56 mg/ml. Similarly, in vivo studies indicated that Phyllanthus emblica 80 mg/kg significantly
reduced the glucose level in diabetic rats up to 166 ± 0.7 mg/dl on day 8th at 8th h as compared to diabetic rats
380 ± 0.7 mg/dl. Similarly, it also reduced the weight in rats up to 274.11 ± 0.97 g as compared to 310.71 ± 0.57
g which was recorded before treatment. It was thus concluded that Phyllanthus emblica is a potent antioxidant
and antidiabetic agent.
ASIFA BASHIR, AAMIR MUSHTAQ, TOOBA MEHBOOB. (2018) Evaluation of Antioxidant and Antidiabetic Activity of Phyllanthus emblica (Fruit), Biologia – Journal of Biological Society of Pakistan, Volume 64 (I), Volume 64 (I).
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