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Background:
Chronic hepatitis C and interferon both have their effect on thyroid gland function including clinical and subclinical thyroidal dysfunction (TD) that form major clinical manifestations of chronic hepatitis c.
Objective:
To assess Pegylated interferon based therapy related thyroidal dysfunction in chronic hepatitis C patients and to compare it with those who are hepatitis C Sero positive but have not receive interferon based treatment.
Methods:
A case control study in which, 203 patients of Chronic, compensated hepatitis C(130 females,73 males) were included from Baqai University Hospital Karachi Liver Clinic (b/w Jan 2010–Jun 2014). The participants were checked for thyroid dysfunction at the onset, 17 patients were found to have thyroidal dysfunction in the beginning and were excluded from the total 203 cases, then out of the remaining 186 cases, 101 patients (who were not having TD initially) opted treatment with pegylated interferon/ribavarin (Treated Group) and the rest (85 cases) were taken as control group.
Results:
Thyroid dysfunction was identified in 7 patients giving a frequency of 6.9%. Out of these 7 patients only one patient was male while the rest were females. The mean age of the patients with thyroid dysfunction was 39.2 ± 7.13 years. Amongst the patients identified with the thyroid dysfunctions, 2 (28.5%) had overt hypothyroidism and 5 (71.4%) had sub-clinical hypothyroidism. The treatment with combination therapy was significant for development of thyroid dysfunction in patients with hepatitis C (p=0.013) as compared to control group in which 85 patients of chronic hepatitis C who have not developed (TD) during the study period.
Conclusion:
dysfunction after pegylated interferon/ribavarin treatment in chronic hepatitis C is statistically significant with sub-clinical hypothyroidism is the predominant type in the study population.
Nida Sajid, Karim Kammeruddin, Muhammad Imran. (2015) Pegylated Interferon Associated Thyroidal Dysfunction Among Hepatitis C Patients, The Pakistan Journal of Medicine and Dentistry, Volume-4, Issue-2.
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