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Background:The useofanti-epilepticdrugsforprophylaxisofearlypost-traumaticseizuresaftertraumaticbraininjuryhasbeenverypromising.The objectiveofthisstudywastodeterminetheoutcomeofphenytoininpreventionofearlypost-traumaticseizuresinmoderatetoseveretraumaticbraininjuriesandtocomparethefrequencyofseizuresinmoderatetoseveretraumaticbraininjury, withphenytoinstartedwithin12hoursandafter12hoursofinjury.Methods: This cross-sectional study was conducted atDepartmentofNeurosurgery, Ayub MedicalInstitute,Abbottabad from April to October,2015.Allthepatientswithmoderatetosevereheadinjurypresentingwithin48hoursofinjurywereincludedinthisstudyinconsecutivemanner. Patientswerestartedonphenytoinandobservedforearlypost-traumaticseizures.Results:Atotalof163patientswereincludedinthisstudywithameanageof24.69±10.186years. One hundred and twenty-two(74.8%)weremalesandrestof41(25.2%)werefemales.Atotalof26(16%)patientshadearlypost-traumaticseizures.9.89% patientsinwhomphenytoinwas started within 12 hours had seizures, while 23.11% patients in whom phenytoin was started after 12 hours of injury had seizures, the difference being statistically significant (p-value .018).Conclusion:Frequency of early post-traumatic seizures is high in patients with moderate to severe head injured patients. Anti-epileptics like phenytoin should be started within 12 hours for seizure prophylaxis.
Shahbaz Ali Khan, Haider Ali Khattak, Gul Muhammad,, Abdul Aziz Khan, Ibrahim Khan, Ahsan Aurangzeb. (2019) EFFICACY OF PHENYTOIN IN PREVENTION OF EARLY POST-TRAUMATIC SEIZURES, JOURNAL OF AYUB MEDICAL COLLEGE ABBOTTABAD, Volume 31, Issue 2.
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