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Background:Preterm births are among the leading causes of fetomaternal mortality and morbidity. Progesterone is routinely used for the treatment of preterm births butscarce data is available that compared the efficacy of oral progesterone (dydrogesterone)withmicronized progesterone(cyclogestpessary/rectal) to reduce the incidence of spontaneous preterm births in our local population.Methods: This randomized controlled trial was conducted at Gynaecologyand Obstetrics department of Combined Military Hospital Nowshera from June to November 2018.Patients were divided into two groups. Group A was given oral progesterone (10 mg twice daily) while group B was given cyclogestpessary (400 mg daily) per rectal use. Efficacy of both groups was compared applying chi-square test and p-value ≤0.05 was considered significant.Results:Total 152 patients were included in study with 1:1 randomization (76 patients in each group). Mean gestational age was 29.6 weeks±1.5SD.Micronized progesterone cyclogestpessary per rectal usage is associated with reduction in preterm C-section, maternal systemic side effects., tocolysis use, NICU admissions, perinatal mortality, intraventricular haemorrhage, oxygen use at 28th day of life and retinopathy of prematurity (p<0.05). An insignificant association between two interventional groups and reason for delivery, antenatal corticosteroids use, birth weight, respiratory distress syndrome, pneumonia, sepsis (p>0.05). Conclusion: Prophylactic micronized progesterone per-rectal use is more effective in reducing preterm birth in patients at high risk of prematurity as compare to oral progesterone (dydrogesterone). Cyclogestpessary 400mg per rectal usage is associated with less maternal and neonatal complications
Nighat Afridi,, Umair Masood,, Salahuddin Balooch, Saifullah Khan, Shahgul Khan. (2019) COMPARISON OF EFFICACY OF ORAL PROGESTERONE AND MICRONIZED PROGESTERONE PESSARY IN REDUCTION OFINCIDENCE OF SPONTANEOUS PRETERM BIRTHS, JOURNAL OF AYUB MEDICAL COLLEGE ABBOTTABAD, Volume 31, Issue 2.
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