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Purpose: Tear TNF-α, IL-1α, and IL-6 levels were investigated in patients with active trachoma.
Material and Methods: Fifteen eyes of 15 patients with active trachoma were included in this study. Active trachoma was diagnosed using fluorescent monoclonal antibody test kit. Fifteen eyes of 15 age-matched, healthy subjects were used as controls. Tear fluid samples were obtained from the conjunctival cul-de-sac by means of blunted-tip glass capillary tubes. Reflex tears from patients with active trachoma and normal subjects were collected by stimulating the nasolacrimal reflex with by a cotton-tipped applicator. The levels of cytokine in tears were measured ELISA.
Results: The tear levels of TNF-α, IL-1α, and IL-6 were determined to be higher in the patients with active trachoma than in the control subjects (p=0.049), (p=0.000), (p=0.003), respectively.
Conclusion: The data suggest that TNF-α and IL-1α with its regulatory cytokine IL-6 may play a role in trachoma. In conclusion, levels of the certain cytokine in tears to reflect inflammation in active trachoma.
Ahmet Satici, Mustafa Guzey. (2009) Tear TNF-?, IL-1?, and IL-6 Levels in Patients with Active Trachoma, Pakistan Journal of Ophthalmology, Volume 25, Issue 3.
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