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Biofilms play an important role in the pathogenesis of many microorganisms. A number of animal and clinical studies have presented importance and role of biofilms in various clinical conditions. This form of growth enables them to grow in form of microbial communities, which help them to grow and survive better. Resistance to antibiotics is usually linked and described as a reason for better survival of microbes in biofilms. In fact, it is not resistance to antibiotics in majority of cases; rather it is ―tolerance‖ of these biofilm communities against antimicrobials. The layers of biofilm provide a protective cover around bacteria and hinder penetration of these agents deep. Furthermore, this tolerance also helps them to survive against immune system, as immune system cells and other components cannot penetrate through layers of biofilm. This review paper discusses important aspects of biofilm formation, clinical importance and the concept of resistance versus tolerance.

Malik Asif Hussain. (2020) Importance and concept of resistance versus tolerance in the biofilm mode of bacterial proliferation, Biologia – Journal of Biological Society of Pakistan, Volume 66(I), Issue 1.
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