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Effects of Diazinon (DZ) were studied at 0, 2.5, 5, 10 and 20 mgkg-1
in adult male mice (10 in each dose
group) for thyroid and parathyroid histopathology. Tissues were recovered following 48 h of DZ treatment.
Micrometric data in terms of follicular size of thyroid, cellular, nuclear sizes of the follicular and chief cells were
obtained from the histological sections. Statistical analysis has shown significant (p<0.001) variations in mean
follicular size of thyroid indicating dose dependent depletion of colloid (thyroglobulin). Mean Cross-Sectional
Area (MCSA) of follicular cells showed increase in DZ groups as compared to the control with maximum rise at
2.5 and 5mg exposure levels while the MCSA of their nuclei remained more-or-less constant. Statistical analysis
has shown significant variation (p<0.05) in MCSA of the follicular cells among the groups. Histopathological
observations revealed dose dependent apoptotic changes in follicular cells and chief cells of parathyroid. Chief
cells MCSA showed slight variations. Nuclear MCSA of the chief cells showed significant (p<0.001) dose
dependent decline. The present findings suggest that DZ is toxic to endocrine cells of thyroid and parathyroidat
5mgkg-1
or more, in mice, bringing about characteristic histopathological and micrometric changes in these
tissues.
SYEDA NADIA AHMAD, MEHWISH NASIR, AQSA NAUREEN, SHAGUFTA ANDLEEB, KAUSAR RAEES, TAHIR ABBAS, ASMA YOUNIS, KHAWAJA RAEES AHMAD. (2018) Histopathological and Micrometric studies of Diazinon exposure on Thyroid and Parathyroid Tissues in Mice, Biologia – Journal of Biological Society of Pakistan, Volume 64 (I), Volume 64 (I).
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