Abstract
Background: Febrile neutropenia is well-known complication in patients on chemotherapy. Despite
the improvement in managements, infections are still major cause of morbidity and mortality. This
study was done to determine the various clinical complications in children with febrile neutropenia and
outcome during the hospital stay in a resource limited setup. Methods: This study was conducted in
Paediatrics Department, Ayub Teaching Hospital, Abbottabad from 2017 to 2019. Children with
diagnosed case of acute lymphoblastic leukaemia (ALL) of age 2−15 years, getting chemotherapy,
presented with fever and neutropenia were included. Clinical complications included
thrombocytopenia, mucositis, profound neutropenia, ANC <100/mm3
and lower respiratory tract
infection. Outcome was taken as improvement (afebrile for 72 hours) or death. Results: Out of 136
patients, 84 (61.8%) were males and 52 (38.2%) were females. Mean age was 6.58±3.49 years. Weight
ranged from 5–58 Kg with mean weight 17.89±8.54. Improvement was in 107 (78.7%) patients while
29 (21.3%) died. Mucositis was in 67.6% patients and lower respiratory tract infection in 57.4%
patients. Platelets count <20,000/mm3 was present in 85 (62.5%) patients. Conclusion: Lower
respiratory tract, mucositis and profound neutropenia are the major complications associated with high
mortality in febrile neutropenia children.
Syed Sajid Hussain Shah, , Mohammad Ali Raza, Shahzad Najeeb, Bibi Aalia, Syed Muhammad Hasnain, Qazi Muhammad Qasim. (2020) CLINICAL COMPLICATIONS AND OUTCOME OF FEBRILE NEUTROPENIA IN CHILDREN AT A TERTIARY CARE HOSPITAL, Pakistan Journal of Physiology, Volume 16, Issue 2.
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