Abstract
Background: Anti-tuberculosis drug resistant is a major public health problem worldwide. It arises due
to improper use of anti-tuberculous drugs in susceptible TB patients. The objectives of this study were
to evaluate treatment outcomes and adverse effects of drug resistant tuberculosis patients. Methods: A
descriptive cross-sectional study was conducted in two Programmatic Management of Drug Resistant
Tuberculosis (PMDT) sites of Sukkur and Larkana. The sociodemographic data was obtained by a set
of questionnaire following WHO guidelines. Adverse drug effects and treatment outcome data was
gathered from their medical files. Results: Of a total 938 patients, 535 (57.1%) were male and 403
(42.9%) were female. Their mean age was 35.95±14.4 years in Sukkur and 35.46±11 years in Larkana.
Married patients were 69%, illiterate were 46.3%, farmers 36.8%, lower class 60.4%, and rural were
68.8% patients. Previously treated cases were 83%. The MDR-TB cases were 82.8%. Diabetes mellitus
as co-morbidity was 11.2%, and 41.3% were smokers. The adverse effects developed in 68.4%
patients. Overall successful treatment outcome rate was 53.9%. Conclusion: Treatment outcome of
drug resistant TB patients was quite low, and 68.4% patients developed adverse effects. Artharlgia was
the most common adverse effect.
Ayaz Ali Unar, Abdullah Dayo, Muhammad Ali Khokhar, Muhammad Ali Ghoto, Khalida Unar. (2020) TREATMENT OUTCOME AND ADVERSE EFFECTS OF DRUG RESISTANT TUBERCULOSIS PATIENTS AT LARKANA AND SUKKUR TUBERCULOSIS CENTRES, Pakistan Journal of Physiology, Volume 16, Issue 2.
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