Abstract
Background: Gestational Diabetes Mellitus (GDM) is a sequence of serious unfavorable maternal and
perinatal outcomes specially if uncontrolled. Although insulin is a standard therapy, Metformin can be used
as an alternative medication to insulin. This study aimed to establish the efficacy, safety, and other
metabolic effects of metformin in GDM due to limited studies in the local population.
Methods: This quasi experimental trial was conducted on pregnant female at 24 weeks of gestation and
above, presenting to Ziauddin Hospital. A total of 361 patients who were diagnosed with GDM were
enrolled. Patients were divided into three groups: diet control, metformin, and metformin with insulin. The Chi
Square and ANOVA were used to compare the maternal and neonatal outcomes. Further post hoc analysis
of significant parameters was done using Tukey HSD test.
Results: Weight gain in pregnancy and gestational age at delivery gives significant mean differences across
three study groups (p=<0.01). In diet control group, weight was significantly gained as compare to metformin
group. Similarly, the gestational age in diet control group was significantly higher as compare to metformin
and metformin with insulin group (p=<0.01). The higher gestational age was found in patients treated with
metformin as compared to metformin with insulin group (37.25±1.41).
Conclusion: Metformin alone as well as in combination with insulin, is a safe, effective treatment option and
more acceptable to women with GDM. Metformin has shown to cause less weight gain during pregnancy
with minimal risk of maternal and neonatal hypoglycemia.
Huma Muzaffar, Shama Chaudhry, Rubina Hussain, Nigar Sadaf. (2020) Efficacy and Safety of Metformin in Gestational Diabetes Mellitus, The Pakistan Journal of Medicine and Dentistry, Volume 9, Issue 4.
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