Abstract
Monotheca buxifolia [(Falc.) A. DC.] indigenous to northern Pakistan is a broad-leaved evergreen
traditional plant of pharmacological versatility. The present investigation focused on evaluating
the phytochemistry, nutritional profile, analgesic activity, cytotoxicity and GC-MS profile of M.
buxifolia. The result showed aerial parts of M. buxifolia had high content of carbohydrate and
protein, along with sufficient amounts of macro and micronutrients. The lipophilic n-hexane
fraction of M. buxifolia exhibited the presence of saponins (29.30%), flavonoids (18%) and
phenols (0.46 mg GAE/100 g). Analgesic activity of lipophilic fraction was equivalent to standard
drug (Aspirin) as determined by the tail flick method. The F1 (oily liquid) of lipophilic fraction
showed significant cytotoxicity against lung adenocarcinoma (A549) and liver (HepG2) cell lines).
GC-MS profiling identified cis-vaccenic acid followed by n-hexadecanoic acid and hexadecanoic
acid, methyl ester as major bioactive compounds in the lipophilic oily sub-fraction of M. buxifolia.
These results support the use of oily sub-fraction of M. buxifolia as an effective and safe candidate
for treatment of cancer cell lines.
Shabnam Javed, Amna Shoaib, Zaid Mahmood, Shaista Nawaz, Khalid Mohammed Khan. (2021) Phytochemical screening, antioxidant, and in vivo neuropharmacological effect of Monotheca buxifolia (Falc.) barks extract, Asian Journal of Agriculture and Biology, Volume-09, Issue-2.
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