Abstract
Background: Diabetes mellitus (DM) increases the risk of adverse outcomes after coronary artery
revascularization. Diabetic patients have a worse prognosis than non-diabetic patients, with generally greater
rates of death, myocardial infarction and need for target lesion and vessel revascularization.
Objectives: The aim of this study was to assess the Short-Term clinical outcomes in diabetic versus non-diabetic
patients who underwent successful percutaneous revascularization with drug-eluting stents.
Material and Methods: Between April 2011 and July 2012, 144 diabetic and 232 non-diabetic patients with
stable coronary disease undergoing DES implantation at Cardiology Unit Lady Reading Hospital, were enrolled
prospectively. Clinical outcomes (Myocardial infarction [MI], unstable angina [UA], and positive ETT) at three
months were measured in Diabetic and non-Diabetic patients who received DES for coronary artery lesions. All
patients were followed and reassessed after 3 months from the index procedure. Exercise Tolerance Test (ETT)
was performed on every patient and recorded on Proforma. Data analysis was done using SPSS version 16.
Results: We evaluated 376 patients with stable coronary artery disease treated with DES of the 376 patients, 144
(38.3%) were Diabetics. The mean age was57±9.313 years. Male patients were 271(72.1%). At 3-Months follow-up,
diabetic patients treated with DES had significantly higher rates for myocardial infarction (5.6 vs. 1.3%; p = 0.025),
unstable angina (12.5 vs. 3.4%; p = 0.001) and positive ETT (16.7 vs. 5.6%; p = 0.001).
Conclusion: Our study revealed that despite the use of DES the risk of myocardial infarction, unstable angina,
and positive ETT at three months remains higher in diabetic patients.
Dr. Yasir Adnan, Lubna Noor, Muhammad Habeel Dar, Haris Adnan. (2017) Short-Term Clinical Outcomes of Drug Eluting Stents in Diabetic versus Non-Diabetic Patients Having Stable Coronary Artery Disease, International Journal of Pathology, Vol-15, Issue 3.
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