Abstract
Hepatitis C virus (HCV) infection is primary cause of liver disease that
leads toward liver cirrhosis and hepatocellular carcinoma. This study
designed to diagnose the prevalence of HCV genotypes circulating in
Gujrat, Punjab. Blood samples of 3540 suspected patient were collected
from July 2017 to January 2019 and analyzed for HCV infection by using
qualitative PCR, confirmed cases were subjected to molecular
genotyping on Real Time PCR (Applied Biosystems, Step One
software). Results show 2750 out of 3540 (77.6%) suspected patients
were positive for HCV-RNA. Female have higher percentage (57.78%)
than male (42.22%) with highest viral load observed at age group 15 to
30 years. The genotype 3a (83.33%) was dominant to other circulating
genotypes as 2b (13.33%) and mixed 3a/2b (3.33%). The highest
prevalence of HCV infection was noted in females compared to males
and 3a was most dominant genotype. This study highlights the new
reported mixed genotypes 3a/2b in this region that should be
remarkable for treatment of high resistant cases of HCV. Further studies
are needed to find out the exact cause of high viral load in this region.
MUHAMMAD NAEEM RAZA, KALSOOM SUGHRA, NADIA ZEESHAN. (2019) Frequency of Hepatitis C virus genotypes circulating in Gujrat Punjab, Pakistan, Biologia – Journal of Biological Society of Pakistan, Volume 65 (II), Issue 2.
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