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Piasinx conoeritratione of oxytetracycline he beer . measured in adult normal buffaloes after a single close of 7.6 rig jkg wadi pha.rmaeokinetie ate lysie wam. clone by one compartracnt open model_ The volume of distribution wa.9 2_12 -1.,01 indicating the maximam'. penetration and tissue localization. The longer half-life for elimination (28,2 ± 5,2 1-1) in buffaloes than in other ..-3poeieil fcrund to be. dae to lower glorrhorular filtration rate. Body clearance, the turn of all clearanoe processes, was 54 ± 17 Beiii.ed on the studies, priming and maintenance doses were auggimited is 5 mind 2. rug/kg at 24 h interval and g and.13.3raiii kg at 48h dosing interval, respectively. The influence or diseased conditions on the predicted plaern.e. levels of thus remains to tai verified experimentally.
INTRODUCTION
The cinvironmental and genetic variations Oan influence the physiological, biochemical and plifirmacologica1 parameters of a. population. Such variaticiro have been obeerved in the renal glom E.ruIar filtration rate {GTB), blood and urine pH at(' renal excretion of urea in iib..etp (Name?. and Shah, 1984). Simi-larly, the glornerular filtration rate was. of lower magnitude. in buffaloem when compared with other tpecies of animals (Hasgan of at., 197D) and the drugs .sneki. Laytetritoydine, which are .xerstir,d mainly through gloznerul.'r filtreition, may persist in the body for dNiger periods of time, .t has having cliffBrent do age rer1nirement3. Therefore, an optimal dosage schedule should be bad on the pharmacoldnotic parameters cle.terrnined in the species and environments in which the drug im to be used clinically..
Bukhtiar H. Shah, M, Nawaz . (1984) Pharmacokinetics and dosage of oxytetracycline in buffaloes, Pakistan Journal of Agricultural Sciences, Volume 21, Issue 3,4.
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