Abstract
Background: Coagulation abnormalities such as thrombosis and disseminated intravascular
coagulation (DIC) are the major factors that play a major role in breast cancer. In the study,
coagulation abnormalities were assessed in breast cancer patients to help the clinician in early
detection of DIC and management of patients at different stages of breast cancer.
Methods: 75 patients were enrolled in the study, 50 were from case group (breast cancer
patients) and 25 were selected as control group subjects used to compare the results. All of
these subjects undergone, General Hematological analysis i.e. differential leukocyte count
hemoglobin,platelets count and total leukocyte count were performed on each of the samples
collected from the subjectsand Specific Hematological analysis i.e. Activated Partial
Thromboplastin Time (APTT), Fibrinogen Assay, Prothrombin Time (PT), D-Dimer
Detection and Fibrin Degradation Products (FDPs).
Results: PT was found to be comparable in patients with breast cancer when compared with
controls. Difference between control group (II) and subjects with breast cancer (I) was nonsignificant, fibrinogen level was found to be significantly increased (p < 0.01) in patients with
different stages of breast cancer when compared with controls. FDPs were found to be
significantly increased (p < 0.01) in patients of breast cancer when compared with control
group. These increased levels of FDPs may be due to enhanced fibrinolysis. D-Dimers were
also found to be significantly increased (p < 0.01) in patients with breast cancer when
compared with controls.
Conclusion: Patients with breast cancer were associated with compensated DIC state
including normal PT and APTT level but increased fibrinogen and platelets count as
compared to the controls. Detection of D-Dimers offers a differential analysis over other
laboratory tests for DIC.
Toraiz Ahmed, Rana Shakil Ahmed, Muhammad Usman Basharat, Muhammad Hassan Mushtaq, Shakira Sadiq Gill, AbdurRehman Khawaja, Arman Khan, Muhammad Farhan Khan. (2013) Comparative study to assess coagulation abnormalities in breast cancer, Advancements in Life Sciences, Volume 1 , Issue 2 .
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