Abstract
OBJECTIVE: To investigate the anti-oxidative and anti-nephrotoxic effects of
resveratrol in cisplatin induced nephrotoxic albino Wistar rats.
METHODS: This quasi-experimental study was performed at Isra University,
Hyderabad, Pakistan. Thirty male albino Wistar rats were divided into three
g roups: g roup-A ( control), g roup-B ( c ispl a tin) and g roup-C
(cisplatin+resveratrol). Biochemical [serum urea, creatinine and glutathione
peroxidase (GPX)] and renal histomorphology was performed in all groups
after 21 days of treatment.
RESULTS: Difference in mean pre- and post-experimental body weight was
observed in all three groups. Mean body weight decreased from 241.7±8.5 gm
to 196.50±9.34 gm and from 237±7.4 gm to 207.2±6.56 gm in group-B and
group-C respectively. In group-A; mean serum urea was 22.7±2.66 mg/dl,
serum creatinine was 0.45±0.05 mg/dl and serum GPX was 1.44±0.13 ηg/ml.
In group-B; mean serum urea level was 51±3.65 mg/dl, mean serum creatinine
was 0.78±0.05 mg/dl and serum GPX was 0.85±0.11 ηg/ml. In group-C, mean
serum urea level was 32.8±1.45 mg/dl, serum creatinine level was 0.41±0.09
mg/dl and serum GPX was 1.53±0.08 ηg/ml. In group-A, renal structure was
intact, marked changes were observed in renal histology of group-B while
group-C displayed less glomerular damage. The mean distance between
visceral and parietal layers of Bowman's capsule was 69.34±0.87 µm in groupA, 216.5±1.32 µm in group-B while 102.22±1.65 µm in group-C. Areas of
peritubular fibrosis and congestion were observed in groups B and C but less
prominent in group-C compared with group-B.
CONCLUSION: Resveratrol therapy is a potent anti-nephrotoxic regime
showing promising results in chemotherapy induced nephrotoxicity and
oxidative stress.
Kumayl Abbas Meghji, Rizwan Ali Talpur, Arsalan Ahmed Uqaili, Yar Muhammad Nizammani, Navaid Kazi, Ghulam Shah Nizammani. (2019) RESVERATROL ATTENUATES OXIDATIVE STRESS IN CHEMOTHERAPY INDUCED ACUTE KIDNEY INJURY: AN EXPERIMENTAL RAT MODEL, KHYBER MEDICAL UNIVERSITY JOURNAL, Volume 11, Issue 2.
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