Abstract
Effects of hypothyroidism on liver and renal parameters and effectiveness
of thyroid treatment (thyroxine) on these factors in hypothyroid subjects
were assessed in the present investigation. A total of 140 subjects (30
subclinical and 50 overt hypothyroid) between the ages of 15-50 years
from INMOL, Lahore and 60 healthy euthyroid controls of the similar age
groups from local population were recruited. Additionally, follow up
studies of nearly thirty five overt hypothyroid patients was also carried out
after taking thyroxine for three months. Serum levels of fT4, fT3 and TSH
were analyzed through Radioimmunoassay (RIA), whereas, levels of
AST, ALT and creatinine were assessed using chemistry analyzer. Levels
of ALT and AST were found significantly increased (P ≤ 0.05) in overt
hypothyroid patients compared to controls and after treatment the
concentrations of both enzymes were decreased non-significantly in post
therapeutic group. Subclinical group also exhibited non-significant
elevation in ALT and AST levels. Creatinine levels were significantly (P ≤
0.05) increased in both subclinical and overt hypothyroid patients and
mildly decreased in follow up group as compared to overt group.
Conclusively, positive association of ALT, AST and creatinine with TSH
and inverse relationship with fT3 and fT4 were observed in hypothyroid
patients that reversed moderately after thyroxine therapy.
ZAHRA NASEEM , MUHAMMAD AMIR IQBAL, SHAAF AHMAD , NABILA ROOHI. (2019) Variations in Hepatorenal profile in Hypothyroid subjects of Lahore, Pakistan, Biologia – Journal of Biological Society of Pakistan, Volume 65 (I), Issue 1.
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