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Structural design of genetic studies has progressed over the last decade
into the most powerful tool for probing the complex human diseases.
There are many different approaches for the identification of genetic risk
factors of the complex diseases. New pharmacological therapies may get
established by understanding the underpinning of biological genetic
effects. We focus here on the applications and strategies that are
currently best suitable for genetic studies which provide preliminary
genetic information for subsequent statistical analyses. Here we review
the basic concept of genetic alterations including monogenic and
polygenic characteristics of complex diseases to determine underlying
genetic complexity and the most appropriate methods for genetic
analysis.
AFIRA WAQAR, ADNAN RAUF, IKRAM-UL HA, BUSHRA CHAUDHRY. (2019) Alterations, complexity and efficient strategies suitable for genetic studies, Biologia – Journal of Biological Society of Pakistan, Volume 65 (II), Issue 2.
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